Klein J. The major histocompatibility complex of the mouse. Science 203:516-21. 1979
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چکیده
lMhc) was discovered as early as 1936 and its function became known in 1974, a great deal ofconfusion persisted for years in regard to its involvement in various immune responses. I formulated a unified hypothesis of the Mhc, according to which only two classes of Mhc loci exist, class I and class II, both participating in the recognition of foreign antigens by T lymphocytes. This hypothesis also provided an explanation for the extraordinary polymorphism of the Mhc loci. [The SCI® indicates that this paper has been cited in over 420 publications.]
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